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In Vivo Imaging Probes

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In Vivo Imaging Probes


In vivo optical imaging techniques might provide opportunities to observe the dynamic real–time localization and translocation of molecules in living cells. In vivo fluorescence imagings are being applied in preclinical research studies, and real–time in vivo studies using animals have been used to track cell–based therapies and to monitor the response to chemotherapies. Other fields of in vivo imaging applications are elucidation of fundamental processes in living organisms or assessment of stem cell differentiation, etc. BioActs provides a range of reagents and probes such as near–infrared (NIR) fluorescent dyes and conjugated probes for in vivo study. The unparalleled photochemical properties of our probes might offer new opportunity in animal and in vivo imaging applications.
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Fluorescent NIR Dyes

Near infrared (NIR) fluorescence is safe and cost effective technique and allows to observe the deep fluorescence image through inside biological tissue. NIR dyes are and used in medical diagnostics, in vitro, vivo and animal model study. BioActs offers a series of NIR dyes such as FSD Fluor™, Flamma® Fluors, and ICG.

FSD Fluor™
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647 680 750  800     
Quick link (Cat.#) FSD Series Ex * (nm) Em* (nm)
KOSC1315 FSD Fluor™ 647 651 667
KOSC1515 FSD Fluor™ 680 679 696
KOSC1702 FSD Fluor™ 750 749 774
POSC1803 FSD Fluor™ 800 774 790

Flamma® 648
20190319090319.png 20190319090319.png 20190319090319.png 20190319090319.png 201903190903083.png 201903190903401.png
NHS ester VInylsulfone Sulfo-NHS  Isothiocynate  Carboxylic acid Maleimide
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Amine Thiol Dichlorotriazine Hydrazide Alkyne PEG4-Alkyne
20190319090319.png 201903190903160.png 201903191003532.png 201903191003400.png    
ADIBO Azide Biotin Streptavidin    
Quick link (Cat.#) FSD Series Ex * (nm) Em* (nm)
PWS1215 Flamma® 648 NHS ester 648 663
PWA1215 Flamma® 648 Vinylsulfone 648 683
PWSN1215 Flamma® 648 Sulfo-NHS ester 648 663
KWI1215 Flamma® 648 Isothiocyanate 648 663
PWC1201 Flamma® 648 Carboxylic acid 648 663
KWM1042 Flamma® 648 Maleimide 648 663
PWE1215 Flamma® 648 Amine 648 663
KWT1042 Flamma® 648 Thiol 648 663
PWR2215 Flamma® 648 Dichlorotriazine 648 667
PWH1215 Flamma® 648 Hydrazide 648 663
PWK1215 Flamma® 648 Alkyne 648 663
PWG1215 Flamma® 648 PEG4-Alkyne 648 663
DWC1021 Flamma® 648 ADIBO 648 663
PWZ1215 Flamma® 648 Azide 648 663
RFP0611 Biotin, Flamma® 648 648 663
RFP0711 Streptavidin, Flamma® 648 648 663

Flamma® 675
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NHS ester VInylsulfone Sulfo-NHS  Isothiocynate  Carboxylic acid Maleimide
20190319100303.png 201903190903173.png 201903190903192.png 20190319090326.png 201903190903091.png 201903190903091.png
Amine Thiol Dichlorotriazine Hydrazide Alkyne PEG4-Alkyne
201903190903091.png 20190319090326.png 201903191003040.png 20190319100349.png    
ADIBO Azide Biotin Streptavidin    
Quick link (Cat.#) FSD Series Ex * (nm) Em* (nm)
PWS1515 Flamma® 675 NHS ester 675 691
PWA1515 Flamma® 675 Vinylsulfone 675 691
PWSN1515 Flamma® 675Sulfo-NHS ester 675 691
KWI1515 Flamma® 675 Isothiocyanate 675 691
PWC1501 Flamma® 675 Carboxylic acid 675 691
PWM1415 Flamma® 675 Maleimide 675 691
PWE1515 Flamma® 675 Amine 675 691
PWT1415 Flamma® 675 Thiol 674 691
PWR2515 Flamma® 675 Dichlorotriazine 675 691
PWH1515 Flamma® 675 Hydrazide 675 691
PWK1515 Flamma® 675 Alkyne 674 691
PWG1515 Flamma® 675 PEG4-Alkyne 674 691
DWC1051 Flamma® 675 ADIBO 674 691
PWZ1515 Flamma® 675 Azide 674 691
RFP0612 Biotin, Flamma® 675 675 691
RFP0712 Streptavidin, Flamma® 675 675 691

Flamma® 749
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NHS ester VInylsulfone Sulfo-NHS  Isothiocynate  Carboxylic acid Maleimide
20190319100312.png 201903190903261.png 20190319090329.png 20190319090335.png 201903190903180.png 201903190903180.png
Amine Thiol Dichlorotriazine Hydrazide Alkyne PEG4-Alkyne
201903190903180.png 20190319090335.png 20190319100313.png 20190319100359.png    
ADIBO Azide Biotin Streptavidin    
Quick link (Cat.#) FSD Series Ex * (nm) Em* (nm)
PWS1301 Flamma® 749 NHS ester 749 774
PWA1308 Flamma® 774 Vinylsulfone 774 795
PWSN1301 Flamma® 749 Sulfo-NHS ester 749 774
PWI1308 Flamma® 749 Isothiocyanate 749 774
PWC1308 Flamma® 749 Carboxylic acid 749 774
PWM1215 Flamma® 749 Maleimide 749 774
PWE1301 Flamma® 749 Amine 749 774
PWT1215 Flamma® 749 Thiol 749 774
PWR2301 Flamma® 749 Dichlorotriazine 749 774
PWH1301 Flamma® 749 Hydrazide 749 774
PWK1301 Flamma® 749 Alkyne 749 774
PWG1301 Flamma® 749 PEG4-Alkyne 749 774
DWC1031 Flamma® 749 ADIBO 749 774
PWZ1301 Flamma® 749 Azide 749 774
RFP0613 Biotin, Flamma® 749 749 774
RFP0713 Streptavidin, Flamma® 749 749 774

Flamma® 774
20190319080314.png 20190319080314.png 20190319080314.png 20190319080314.png 201903190903261.png 201903190903000.png
NHS ester VInylsulfone Sulfo-NHS  Isothiocynate  Carboxylic acid Maleimide
20190319100312.png 201903190903261.png 20190319090329.png 20190319090335.png 201903190903180.png 201903190903180.png
Amine Thiol Dichlorotriazine Hydrazide Alkyne PEG4-Alkyne
201903190903180.png 20190319090335.png 20190319100313.png 20190319100313.png    
ADIBO Azide Biotin Streptavidin    
Quick link (Cat.#) FSD Series Ex * (nm) Em* (nm)
PWS1603 Flamma® 774 NHS ester 774 800
PWA1603 Flamma® 774 Vinylsulfone 774 795
PWSN1603 Flamma® 774 Sulfo-NHS ester 774 800
PWI1603 Flamma® 774 Isothiocyanate 774 800
PWC1603 Flamma® 774 Carboxylic acid 774 800
PWM1515 Flamma® 774 Maleimide 774 806
PWE1603 Flamma® 774 Amine 774 800
PWT1515 Flamma® 774 Thiol 774 800
PWR2603 Flamma® 774 Dichlorotriazine 774 800
PWH1603 Flamma® 774 Hydrazide 774 800
PWK1603 Flamma® 774 Alkyne 774 800
PWG1603 Flamma® 774 PEG4-Alkyne 774 800
DWC1061 Flamma® 774 ADIBO 774 800
PWZ1603 Flamma® 774 Azide 774 800
RFP0614 Biotin, Flamma® 774 774 806
RFP0714 Streptavidin, Flamma® 774 774 806

Flamma® 800
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VInylsulfone          
Quick link (Cat.#) FSD Series Ex * (nm) Em* (nm)
POA1803 Flamma® 800 Vinylsulfone 774 789

ICG Dye
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ICG ICG (water-soluble) NHS ester Vinylsulfone Sulfo-NHS ester Isothiocyanate
201903190903261.png 201903190903000.png 20190319100312.png 201903190903261.png 20190319090329.png 20190319090335.png
Carboxylic acid Maleimide Amine Thiol Dichlorotriazine Hydrazide
201903190903180.png 201903190903180.png 201903190903180.png 20190319090335.png    
Alkyne PEG4-Alkyne ADIBO Azide    
 
Quick link (Cat.#) Series Quick link (Cat.#) Series
RFP0815 ICG RFP0915 ICG (water-soluble)
POS1604 ICG NHS ester POA1616 ICG Vinylsulfone
POSN1604 ICG Sulfo-NHS ester POI1616 ICG Isothiocyanate
POC1616 ICG Carboxylic acid PWM1301 ICG Maleimid
POE1616 ICG Amine PWT1301 ICG Thiol
POR2616 ICG Dichlorotriazine POH1616 ICG Hydrazide
POK1616 ICG Alkyne POG1616 ICG PEG4-Alkyne
DOC1061 ICG ADIBO POZ1616 ICG Azide
 

In Vivo Imaging Probes (Fluorescence)

NpFlamma® HGC series
NpFlamma® HGC series is a fluorescent dye incorporated biocompatible and biodegradable chitosan based amphiphilic nanoparticle that enables to selectively detect tumor cells. Chitosan nanoparticles can selectively accumulate in cancer tissues due to high permeability for loose new blood vessels around cancer tissues and retention effect. The polymeric nanoparticles form self-aggregates size of several hundred nanometers in the aqueous system accumulate only in vicinity of cancer tissues. Chitosan particles display low toxicity along with absence of noticeable side effect in vivo, yet they exhibit a long half-life, high stability and aqueous solubility. Thus, NpFlamma® HGC series is an ideal fluorescence agent for in vivo imaging of angiography and tumor progression. In conjunction with NIR dyes, the series allows to observe non-invasive images of cancer metastases and to contrast blood vessel. The hydrophobic nature of NpFlamma® HGC series can embed hydrophobic materials, thus they can be utilized as a selective carrier for hydrophobic cancer drugs such as doxorubicin and paclitaxel, etc. In addition, carboxylic acids on the surface of NpFlamma® HGC series can bind to a variety of biomolecules via amide or ester linkages enabling to utilize them in multi-purposes.

NpFlamma® MMP series
Matrix metalloproteinases (MMPs) are a group of calcium-dependent, zinc-containing endopeptidases that that in concert are responsible for the degradation of most extracellular matrix (ECM) proteins during organogenesis, growth and normal tissue turnover. Humans have 23 MMPs family, and the expression and activity of MMPs in adult tissues is normally quite low, but increases significantly in various pathological conditions that may lead into unwanted tissue destruction, tumor growth and metastasis, inflammatory diseases, etc. Cancer cells secrete VEGF and FGF in order to induce angiogenesis in vascular endothelial cells, but cannot reach to vascular endothelial cells as being caught in ECM. Although MMPs are connected with cancer cells survival and expansion, only very small amount of MMPs are synthetized by cancer cell. However, the cancer cells induce inflammatory cells to secrete MMPs for assisting the delivery of VEGF secreted by cancer cells and make peripheral space for angiogenesis. The connection between MMPs and apoptosis, cell migration and angiogenesis enables to utilizing MMPs as tumor markers. An increased expression and activity of MMPs in both tissues and blood of patients with various types of cancer is observed.

Annexin V Flamma® series
Annexin V Flamma® series is a rapid and selective probe for labeling of externalized PS, an indicator of intermediate stages of apoptosis. Flamma® dyes display strong absorption, high fluorescence quantum yield and high photostability, and they maintain good fluorescence activity and stability after conjugation to biomolecules, allowing the detection of low-abundance biological structures with great sensitivity. Annexin V Flamma® conjugates can be utilized in fluorescent imaging as well as for flow cytometry of apoptotic cells, and they might be used in combination with other dyes such as propidium iodide (PI) in order to accurately analyze mixed populations of apoptotic and other cells. Annexin V Flamma® probes available as stand-alone reagent or easy-to-us kits.

ApoFlamma® series
ApoFlamma® H series made up of a covalent-connection of CQRPPR hexapeptide (ApoPep) with corresponding fluorophore. ApoPep strongly binds to apoptotic and necrotic cells but weakly binds to live cells. The receptor for ApoPep was histone H1 that exposed on the surface of apoptotic cells. In necrotic cells, ApoPep entered the cells and bound to histone H1. The monitoring of tumor apoptosis in response to chemotherapy can be easily realized with optical imaging technique utilizing ApoFlamma® H series. We recommend ApoFlamma® H series as versatile fluorescent probes for in vitro and in vivo imaging of apoptosis with targeting for histone H1.

AngioFlamma® series
Integrins are heterodimeric transmembrane receptors for cell adhesion to extracellular matrix (ECM) proteins and play important roles in certain cell-cell adhesions. In addition, they make transmembrane connections to the cytoskeleton and activate many intracellular signaling pathways. Because of their role in tumor angiogenesis and progression, integrins have become important diagnostic and therapeutic targets. To date 24 distinct integrins are known, and among them, integrin αvβ3 is known to strongly involve in the regulation of angiogenesis. The αvβ3 is generally expressed in low levels on the epithelial cells and mature endothelial cells, but it is highly expressed in many solid tumors. The αvβ3 levels correlate well with the potential for tumor metastasis and aggressiveness, which make it an important biological target for development of antiangiogenic drugs and molecular imaging probes for early tumor diagnosis.
 

NpFlamma® HGC Series
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648 675 749  774  HGC IGC  
 
Quick link (Cat.#) Series Ex * (nm) Em* (nm) Common
filter set		 Excitation
source
PNC1201 NpFlamma® HGC 648 648 675 Cy 5 594, 633 nm
PNC1401 NpFlamma® HGC 675 675 698 Cy 5.5 633, 680 nm
PNC1301 NpFlamma® HGC 749 750 782 Cy 7 680 nm
PNC1601 NpFlamma® HGC 774 777 802 Cy 7.5 785 nm
PNC1501 NpFlamma® HGC ICG 785 821 Cy 7.5 785 nm

NpFlamma® MMP Series
20190319110352.png 201903191103021.png 201903191103131.png 201903191103131.png 201903191103131.png 20190319110352.png
MMP-2,9 648 MMP-2,9 675 MMP-2,9 749 MMP-2,9 774 MMP-2,9 ICG MMP-3,7 648
201903191103021.png 201903191103131.png 201903191103131.png 201903191103131.png 20190319110352.png 201903191103021.png
MMP-3,7 675 MMP-3,7 749 MMP-3,7 774 MMP-3,7 ICG MMP-13 648 MMP-13 675
201903191103131.png 201903191103131.png 201903191103131.png      
MMP-13 749 MMP-13 774 MMP-13 ICG      
 
Quick link (Cat.#) Series Ex * (nm) Em* (nm) Common
filter set		 Excitation
source
PNM0103 NpFlamma® MMP-2,9 648 648 670 Cy 5 594, 633 nm
PNM0104 NpFlamma® MMP-2,9 675 683 694 Cy 5.5 633, 680 nm
PNM0105 NpFlamma® MMP-2,9 749 760 778 Cy 7 785 nm
PNM0106 NpFlamma® MMP-2,9 774 793 810 Cy 7.5 785 nm
PNM0101 NpFlamma® MMP-2,9 ICG 798 835 Cy 7.5 785 nm
PNM0203 NpFlamma® MMP-3,7 648 648 670 Cy 5 594, 633 nm
PNM0204 NpFlamma® MMP-3,7 675 683 694 Cy 5.5 633, 680 nm
PNM0205 NpFlamma® MMP-3,7 749 760 778 Cy 7 785 nm
PNM0206 NpFlamma® MMP-3,7 774 793 810 Cy 7.5 785 nm
PNM0201 NpFlamma® MMP-3,7 ICG 798 835 Cy 7.5 785 nm
PNM0303 NpFlamma® MMP-13 648 648 670 Cy 5 594, 633 nm
PNM0304 NpFlamma® MMP-13 675 683 694 Cy 5.5 633, 680 nm
PNM0305 NpFlamma® MMP-13 749 760 778 Cy 7 785 nm
PNM0306 NpFlamma® MMP-13 774 793 810 Cy 7.5 785 nm
PNM0301 NpFlamma® MMP-13 ICG 798 835 Cy 7.5 785 nm

Annexin V Flamma® Series
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648 675 749 774 V-ICG  
 
Quick link (Cat.#) Series λEx (nm) λEm (nm)
XAP1102 Annexin V-FITC Apoptosis detection kit 492 519
XAP1201 Annexin V-Flamma® 488 Apoptosis detection kit 549 564
XAP1301 Annexin V-Flamma® 552 Apoptosis detection kit 648 672
XAP1801 Annexin V-TAMRA Apoptosis detection kit 648 672
XAP2102 Annexin V-FITC 492 519
XAP2202 Annexin V-Flamma® 488 495 519
XAP2302 Annexin V-Flamma® 552 550 565
XAP2802 Annexin V-TAMRA 543 575
XAP2402 Annexin V-Flamma® 648 648 663
XAP2022 Annexin V-Flamma® 675 675 691
XAP2032 Annexin V-Flamma® 749 749 774
XAP2042 Annexin V-Flamma® 774 774 806
XAP2052 Annexin V-ICG 785 821

AngioFlamma® Series
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648 675 749 774 ICG
 
Quick link (Cat.#) Series λEx (nm) λEm (nm) Common filter set Excitation source Size
ARW1025 AngioFlamma® FAM 492 519 FITC 488 nm 0.5mg, 1mg, 5mg
ARW1011 AngioFlamma® 552 550 565 TRITC 488, 532 nm 0.5mg, 1mg, 5mg
ARR1001 AngioFlamma® TAMRA 543 575 TRITC 488, 532 nm 0.5mg, 1mg, 5mg
ARW1415 AngioFlamma® 581 581 596 TRITC 488, 532 nm 0.5mg, 1mg, 5mg
ARW1215 AngioFlamma® 648 648 663 Cy®5 594, 633 nm 0.5mg, 1mg, 5mg
ARW1501 AngioFlamma® 675 675 691 Cy®5.5 633, 680 nm 0.5mg, 1mg, 5mg
ARW1301 AngioFlamma® 749 749 774 Cy®7 680 nm 0.5mg, 1mg, 5mg
ARW1601 AngioFlamma® 774 774 806 Cy®7.5 785 nm 0.5mg, 1mg, 5mg
ARO1601 AngioFlamma® ICG 785 821 Cy®7.5 785 nm 0.5mg, 1mg, 5mg

ApoFlamma® Series
Diagnocine-F1.png Diagnocine-F1.png Diagnocine-F1.png Diagnocine-F1.png Diagnocine-F1.png  
648 675 749 774 ICG  
 
Quick link (Cat.#) Series Ex * (nm) Em* (nm)
AHW1215 ApoFlamma® H 648 648 663
AHW1501 ApoFlamma® H 675 675 691
AHW1301 ApoFlamma® H 749 749 774
AHW1601 ApoFlamma® H 774 774 806
AHO1601 ApoFlamma® H ICG 785 812
 

NIR Cell (Membrane) Tracers

The analysis of live cell membranes and liposome bilayers represents a significant area of application for fluorescent probes. Lipophilic organic dyes bear some structural resemblance to natural lipids and can be incorporated into cell wall and liposome. BioActs developed CytoFlamma® cell membrane series as versatile membrane selective fluorescent probes. The probes consist of Flamma dye attached with hydrophobic lipid analogs. They can be used in studies for biophysical analysis of membranes, for tracing lipid transport and metabolism in live cells, and for lipid-mediated signal transduction processes. Flamma® dyes display strong absorption, high fluorescence quantum yield and high photostability, and they maintain good fluorescence activity and stability after conjugation to biomolecules. Due to low toxicity and stable retention, CytoFlamma® cell membrane probes might be useful for long-term cell tracing and can be used as membrane markers of endocytosis and exocytosis. The probes are stable under photooxidation effects induced by ultraviolet excitation and are resistant to spontaneous oxidation. We offer CytoFlamma® cell membrane series as selective fluorescent probes for analyzing cell structure by incorporating into plasma membrane.

CytoFlamma® Series
Diagnocine-F1.png Diagnocine-F1.png Diagnocine-F1.png Diagnocine-F1.png                                                                                                                                                                                          
648/672 (1 mM) 648/672 (5 mM) 756/785 (1 mM) 756/785 (5 mM)    
 
Quick link (Cat.#) Series λEx (nm) λEm (nm) Packing unit
RCS1322 CytoFlamma® 552 Cell-membrane (1 mM) 549 564 1 mL
RCS1323 CytoFlamma® 552 Cell-membrane (5 mM) 549 564 1 mL
RCS1422 CytoFlamma® 648 Cell-membrane (1 mM) 648 672 1 mL
RCS1423 CytoFlamma® 648 Cell-membrane (5 mM) 648 672 1 mL
RCS1622 CytoFlamma® 749 Cell-membrane (1 mM) 756 785 1 mL
RCS1623 CytoFlamma® 749 Cell-membrane (5 mM) 756 785 1 mL

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